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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2023
Affiliation
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA;; Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center; NY, USA;; Columbia Magnetic Resonance Research Center (CMRRC), Columbia University, USA. Electronic address: WS2003@columbia.edu.; Liver Imaging Group, Department of Radiology, UCSD School of Medicine, San Diego, CA, USA.; Department of Radiology, University of Washington, Seattle, WA, USA.; Liver Imaging Group, Department of Radiology, UCSD School of Medicine, San Diego, CA, USA.; Computational and Applied Statistics Laboratory (CASL), San Diego Supercomputer Center at UCSD, San Diego, CA, USA.; Computational and Applied Statistics Laboratory (CASL), San Diego Supercomputer Center at UCSD, San Diego, CA, USA;; Department of Mathematics, UCSD, San Diego, CA, USA.; Liver Imaging Group, Department of Radiology, UCSD School of Medicine, San Diego, CA, USA.; Emory University School of Medicine, Department of Radiology and Imaging Sciences and Children's Healthcare of Atlanta, Atlanta, GA, USA.; Department of Radiology, Cincinnati Children's Hospital Medical Center and Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.; Section of Abdominal Imaging and Nuclear Medicine Department, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA;; Center for Advanced Magnetic Resonance Development, (CAMRD), Department of Radiology, Duke University Medical Center, Durham, NC, USA;; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA.; NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California-San Diego, La Jolla, CA, USA.; Saint Louis University, St. Louis, MO, USA.; Virginia Commonwealth University, Richmond, VA, USA.; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.; Liver Imaging Group, Department of Radiology, UCSD School of Medicine, San Diego, CA, USA.; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA;; Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University Irving Medical Center; NY, USA.
Authors
Shen Wei, Middleton Michael S, Cunha Guilherme M, Delgado Timoteo I, Wolfson Tanya, Gamst Anthony, Fowler Kathryn J, Alazraki Adina, Trout Andrew T, Ohliger Michael A, Shah Shetal N, Bashir Mustafa R, Kleiner David E, Loomba Rohit, Neuschwander-Tetri Brent A, Sanyal Arun J, Zhou Jane, Sirlin Claude B, Lavine Joel E
Studies

Abstract

Non-alcoholic steatohepatitis (NASH) is prevalent in adults with obesity and can progress to cirrhosis. In a secondary analysis of prospectively acquired data from the multicenter, randomized, placebo-controlled FLINT trial, we investigated the relationship between reduction in adipose tissue compartment volumes and hepatic histologic improvement.