An official website of the United States government
Publication Information
Affiliation
Renal Section VA Eastern Colorado Healthcare SystemAurora CO.; Division of Nephrology/Hypertension Northwestern University Chicago IL.; Division of Nephrology/Hypertension Northwestern University Chicago IL.; Nephrology and Hypertension Tulane University New Orleans LA.; Nephrology and Hypertension Tulane University New Orleans LA.; Division of Nephrology University of Michigan Ann Arbor MI.; Division of Nephrology University of Illinois at Chicago Chicago IL.; Division of Nephrology Case Western Reserve University Cleveland OH.; Division of Research Kaiser Permanente Northern California Oakland CA.; Division of Nephrology University of Mississippi Jackson MI.; Division of Renal Electrolyte and Hypertension University of Pennsylvania Philadelphia PA.; Nephrology Division Massachusetts General HospitalHarvard Medical School Boston MA.; Division of Renal Diseases and Hypertension University of Colorado Anschutz Medical Campus Aurora CO.; Division of Nephrology/Hypertension Northwestern University Chicago IL.; Division of Renal Diseases and Hypertension University of Colorado Anschutz Medical Campus Aurora CO.
Authors
Jovanovich Anna, Cai Xuan, Frazier Rebecca, Bundy Josh D, He Jiang, Rao Panduranga, Lora Claudia, Dobre Mirela, Go Alan, Shafi Tariq, Feldman Harold I, Rhee Eugene P, Miyazaki Makoto, Isakova Tamara, Chonchol Michel
Studies
Abstract
Background Deoxycholic acid (DCA) is a secondary bile acid that may promote vascular calcification in experimental settings. Higher DCA levels were associated with prevalent coronary artery calcification (CAC) in a small group of individuals with advanced chronic kidney disease. Whether DCA levels are associated with CAC prevalence, incidence, and progression in a large and diverse population of individuals with chronic kidney disease stages 2 to 4 is unknown. Methods and Results In the CRIC (Chronic Renal Insufficiency Cohort) study, we evaluated cross-sectional (n=1057) and longitudinal (n=672) associations between fasting serum DCA levels and computed tomographic CAC using multivariable-adjusted regression models. The mean age was 57±12 years, 47% were women, and 41% were Black. At baseline, 64% had CAC (CAC score >0 Agatston units). In cross-sectional analyses, models adjusted for demographics and clinical factors showed no association between DCA levels and CAC >0 compared with no CAC (prevalence ratio per 1-SD higher log DCA, 1.08 [95% CI, 0.91-1.26). DCA was not associated with incident CAC (incidence per 1-SD greater log DCA, 1.08 [95% CI, 0.85-1.39]) or CAC progression (risk for increase in ≥100 and ≥200 Agatston units per year per 1-SD greater log DCA, 1.05 [95% CI, 0.84-1.31] and 1.26 [95% CI, 0.77-2.06], respectively). Conclusions Among CRIC study participants, DCA was not associated with prevalent, incident, or progression of CAC.