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Publication Information
Affiliation
Critical Care Medicine.; Critical Care Medicine.; School of Public Health, University of Pittsburgh, Pittsburgh, PA.; School of Public Health, University of Pittsburgh, Pittsburgh, PA.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Texas Southwestern Medical Center, Children's Health, Dallas, TX.; Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia.; Department of Surgery, University of Pittsburgh.; Department of Surgery, University of Pittsburgh.; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Authors
Toney Nicole A, Bell Michael J, Belle Steven H, Hardison Regina M, Rodriguez-Baez Norberto, Loomes Kathleen M, Vodovotz Yoram, Zamora Ruben, Squires Robert H
Studies
Abstract
Pediatric acute liver failure (PALF) is a public heath burden, often requiring prolonged hospitalization and liver transplantation. Hepatic encephalopathy (HE) is a complication of PALF with limited diagnostic tools to predict outcomes. Serum neurological markers (neuron-specific enolase, S100β, and myelin basic protein) can be elevated in traumatic or ischemic brain injury. We hypothesized that these neuromarkers would be associated with the development of HE in PALF.