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Publication Information
Affiliation
Department of Family Medicine and Public Health , School of Medicine, University of California San Diego , La Jolla, CA , USA.; Department of Family Medicine and Public Health , School of Medicine, University of California San Diego , La Jolla, CA , USA.; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA; Department of Medicine (Nephrology), University of California San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Psychiatry , School of Medicine, University of California San Diego , La Jolla, CA , USA.; Division of Nephrology and Hypertension , Georgetown University Medical Center , Washington, DC , USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA.; Department of Psychiatry , School of Medicine, University of California San Diego , La Jolla, CA , USA.; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA; Department of Medicine (Nephrology), University of California San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Authors
Bhatnagar Vibha, Richard Erin L, Wu Wei, Nievergelt Caroline M, Lipkowitz Michael S, Jeff Janina, Maihofer Adam X, Nigam Sanjay K
Studies
Abstract
In the setting of chronic kidney disease (CKD), altered extra-renal urate handling may be necessary to regulate plasma uric acid. The Remote Sensing and Signaling Hypothesis (Nigam S. What do drug transporters really do? Nat Rev Drug Discov 2015; 14: 29-44) suggests that multispecific solute carrier (SLC) and ATP-binding cassette (ABC) drug transporters in different tissues are part of an inter-organ communication system that maintains levels of urate and other metabolites after organ injury.