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Publication Information
Authors
Li Yun R., van Setten Jessica, Verma Shefali S., Lu Yontao, Holmes Michael V., Gao Hui, Lek Monkol, Nair Nikhil, Chandrupatla Hareesh, Chang Baoli, Karczewski Konrad J., Wong Chanel, Mohebnasab Maede, Mukhtar Eyas, Phillips Randy, Tragante Vinicius, Hou Cuiping, Steel Laura, Lee Takesha, Garifallou James, Guettouche Toumy, Cao Hongzhi, Guan Weihua, Himes Aubree, van Houten Jacob, Pasquier Andrew, Yu Reina, Carrigan Elena, Miller Michael B., Schladt David, Akdere Abdullah, Gonzalez Ana, Llyod Kelsey M., McGinn Daniel, Gangasani Abhinav, Michaud Zach, Colasacco Abigail, Snyder James, Thomas Kelly, Wang Tiancheng, Wu Baolin, Alzahrani Alhusain J., Al-Ali Amein K., Al-Muhanna Fahad A., Al-Rubaish Abdullah M., Al-Mueilo Samir, Monos Dimitri S., Murphy Barbara, Olthoff Kim M., Wijmenga Cisca, Webster Teresa, Kamoun Malek, Balasubramanian Suganthi, Lanktree Matthew B., Oetting William S., Garcia-Pavia Pablo, MacArthur Daniel G., de Bakker Paul I W, Hakonarson Hakon, Birdwell Kelly A., Jacobson Pamala A., Ritchie Marylyn D., Asselbergs Folkert W., Israni Ajay K., Shaked Abraham, Keating Brendan J.
Studies
Abstract
In addition to HLA genetic incompatibility, non-HLA difference between donor and recipients of transplantation leading to allograft rejection are now becoming evident. We aimed to create a unique genome-wide platform to facilitate genomic research studies in transplant-related studies. We designed a genome-wide genotyping tool based on the most recent human genomic reference datasets, and included customization for known and potentially relevant metabolic and pharmacological loci relevant to transplantation.