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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2021
Affiliation
Division of Pediatric Nephrology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.; Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, WA, USA.; Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, WA, USA.; Department of Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC, USA.; Division of Research, Kaiser Permanente Northern California, San Francisco, CA, USA.; Department of General Internal Medicine, San Francisco VA Medical Center, San Francisco, CA, USA.; Departments of Medicine and Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Departments of Medicine and Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, WA, USA.; Translational Science Institute School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, LA, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, LA, USA.; Inova Heart and Vascular Institute, Falls Church, VA, USA.; Departments of Medicine and Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, School of Medicine, Duke University, Durham, NC, USA.; National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.; Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Translational Science Institute School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.; Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, WA, USA.
Authors
Kula Alexander J, Katz Ronit, Zelnick Leila R, Soliman Elsayed, Go Alan, Shlipak Michael, Deo Rajat, Ky Bonnie, DeBoer Ian, Anderson Amanda, Christenson Rob, Seliger Stephen L, Defilippi Chris, Feldman Harold I, Wolf Myles, Kusek John, Shafi Tariq, He Jiang, Bansal Nisha
Studies

Abstract

Among patients with chronic kidney disease (CKD), the circulating cardiac biomarkers soluble ST2 (SST2), galectin-3, growth differentiation factor-15 (GDF-15), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin-T (hsTnT) possibly reflect pathophysiologic processes and are associated with clinical cardiovascular disease. Whether these biomarkers are associated with electrocardiographic findings is not known. The aim of this study was to test the association between serum cardiac biomarkers and the presence of electrocardiographic changes potentially indicative of subclinical myocardial disease in patients with CKD.