NIDDK Central Repository - Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: associations with antiviral treatment outcomes.

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NIDDK Central Repository

Publication Information

DOI

10.1136/gut.2008.168948

PubMed ID

19193669

Public Release Type

Journal

Publication Year

2009

Affiliation

Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Denver, Colorado, USA.

Authors

Castelblanco N, Dillon SM, Golden-Mason L, Im KA, Mengshol JA, Rosen HR, Virahep-C Study Group, Wilson CC

Studies

Virahep-C

Citation

Mengshol JA, Golden-Mason L, Castelblanco N, Im KA, Dillon SM, Wilson CC, Rosen HR, Virahep-C Study Group. Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: associations with antiviral treatment outcomes. Gut 2009 Jul;58(7):964-73. Epub 2009 Feb 4.

Abstract

Dendritic cell (DC) defects may contribute to chronicity in hepatitis C virus (HCV) infection and determine response to PEG-interferon and ribavirin therapy via poor T cell stimulation. Studies to date have produced inconsistent results regarding DC maturation and function: no large study has examined DCs before and after therapy.